1.Wolfgang B.Liedtkea,b,1,2.Michael J.McKinleyc,d,
3.Lesley L.Walkerc,2,
4.Hao Zhangb,2,
5.Andreas R.Pfenningb,2,
6.John Dragoc,e,
7.Sarah J.Hochendonera,b,
8.Donald L.Hiltonf,
9.Andrew J.Lawrencec,e, and
10.Derek A.Dentonc,g,h,1
+ Author Affiliations
1. Departments of aMedicine/Neurology and
2. bNeurobiology, Duke University, Durham, NC 27710;
3. cFlorey Neuroscience Institutes,
4. dDepartment of Physiology,
5. eCenter for Neuroscience, and
6. gOffice of the Dean, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, VIC 3010, Australia;
7. fDepartment of Neurosurgery, University of Texas Health Science Center, San Antonio, TX 78229; and
8. hBaker Heart Research Institute, Melbourne, Victoria 3004, Australia
1. Contributed by Derek A.Denton, June 7, 2011 (sent for review April 1, 2011)
Abstract
Sodium appetite is an instinct that involves avid specific intention.It is elicited by sodium deficiency, stress-evoked adrenocorticotropic hormone (ACTH), and reproduction.Genome-wide microarrays in sodium-deficient mice or after ACTH infusion showed up-regulation of hypothalamic genes, including dopamine- and cAMP-regulated neuronal phosphoprotein 32 kDa (DARPP-32), dopamine receptors-1 and -2, О
